DNA Testing

ApoE

Apolipoprotein E (ApoE) is a gene involved in the metabolism of fats in the body. Variants of the ApoE gene can influence an individual's risk of developing conditions such as cardiovascular disease and Alzheimer's disease. Understanding your ApoE genotype can help in assessing your risk and guiding personalized preventive strategies.

Abacavir Hypersensitivity

HLA-B5701 is a genetic marker that can predict hypersensitivity to the HIV medication abacavir. Testing for the HLA-B5701 allele helps identify patients at risk of severe allergic reactions, ensuring safer and more effective treatment options.

Addison's Disease

HLA-DRB1 is a genetic marker associated with an increased risk of developing autoimmune conditions like Addison's disease. Testing for HLA-DRB1 can help identify individuals predisposed to this adrenal gland disorder, aiding in early diagnosis and personalized care strategies.

Allopurinol Hypersensitivity

HLA-B58:01 is a genetic marker linked to an increased risk of severe hypersensitivity reactions to the medication allopurinol, commonly used to treat gout. Testing for the HLA-B58:01 allele can help identify patients at risk, allowing for safer medication choices and personalized treatment plans.

Ankylosing Spondylitis

HLA-B is a genetic marker strongly associated with ankylosing spondylitis, a type of inflammatory arthritis that primarily affects the spine. Testing for the HLA-B27 variant can help in diagnosing ankylosing spondylitis, leading to earlier intervention and tailored treatment strategies for managing symptoms.

Behcet's Disease

HLA-B is a genetic marker associated with an increased risk of Behcet's disease, a rare inflammatory disorder causing blood vessel inflammation throughout the body. Testing for specific HLA-B variants, such as HLA-B51, can aid in the diagnosis and management of Behcet's disease, guiding personalized treatment approaches.

Birdshot Chorioretinopathy

HLA-A is a genetic marker linked to birdshot chorioretinopathy, a rare autoimmune eye disease that causes inflammation of the retina. Testing for the HLA-A29 variant can help diagnose birdshot chorioretinopathy, enabling timely and targeted treatment to preserve vision and manage symptoms.

CBS

Mutations in the CBS gene can lead to a condition known as homocystinuria, characterized by an inability to properly metabolize homocysteine. This results in an accumulation of homocysteine and related compounds in the blood and urine, leading to a range of symptoms and complications, including: cardiovascular disease, skeletal abnormalities (e.g. osteoporosis), eye problems, neurological issues, and thromboembolic events (heart attacks, strokes, etc). Testing for CBS gene mutations, along with measuring homocysteine and ammonia levels, is essential for diagnosing and managing homocystinuria. Early diagnosis allows for dietary modifications, vitamin supplementation, and other treatments to reduce homocysteine levels and mitigate the disease's impact.

COMT

COMT (catechol-O-methyltransferase) is an enzyme involved in the breakdown of neurotransmitters such as dopamine, norepinephrine, and epinephrine. Variations in the COMT gene can affect its activity, influencing neurotransmitter levels and thereby impacting pain perception and stress response.

Estradiol, a form of estrogen, also plays a role in modulating pain perception and stress response through various mechanisms, including interaction with neurotransmitter systems.

Testing COMT activity and estradiol levels can provide insights into how an individual processes pain and responds to stress, guiding personalized approaches to pain management and stress reduction strategies. These tests are particularly relevant in conditions where pain and stress are prominent factors, such as chronic pain syndromes and mood disorders.

Carbamazepine Hypersensitivity

HLA-B15:02 is a genetic marker associated with an increased risk of hypersensitivity reactions to carbamazepine, a commonly prescribed medication for epilepsy and other neurological disorders. Testing for HLA-B15:02 before starting carbamazepine helps identify individuals at higher risk for severe skin reactions such as Stevens-Johnson syndrome and toxic epidermal necrolysis. This information enables healthcare providers to choose alternative medications or adjust dosages to avoid potentially life-threatening reactions.

Cardiac Health

Discover your risk of forming blood clots, high blood pressure, plaque development, alterations in lipid transport, and how your body might respond to/metabolize statin medications (commonly prescribed to lower blood cholesterol levels).

Celiac Disease

HLA-DQA1 and HLA-DQB1 are genetic markers associated with an increased risk of developing celiac disease, an autoimmune disorder triggered by the ingestion of gluten. These genes encode proteins that are part of the human leukocyte antigen (HLA) complex, responsible for regulating the immune system's response to foreign substances.

Testing for specific variants of HLA-DQA1 and HLA-DQB1 can help identify individuals who are genetically predisposed to celiac disease. However, it's important to note that not everyone with these genetic markers will develop the disease, as additional environmental factors also play a role in its onset.

This genetic testing is particularly useful in cases where there is uncertainty about a celiac disease diagnosis or when screening individuals with a family history of the condition. Identifying at-risk individuals early allows for appropriate monitoring and dietary management to prevent complications associated with gluten intolerance.

Comprehensive Genetic Panel

This comprehensive panel looks at your risk profile across a variety of conditions:

• Cardiac health

• Weight management

• Nutrition

• Graceful aging

• Methylation

• Mood and brain disorders

• Diabetes risk 

Grave's Disease

HLA-DRB1 is a genetic marker associated with an increased susceptibility to autoimmune diseases like Graves' disease, which is characterized by an overactive thyroid gland (hyperthyroidism). Testing for HLA-DRB1 variants can help identify individuals who may be predisposed to autoimmune thyroid disorders, including Graves' disease. This information is valuable for early detection, personalized treatment planning, and monitoring of thyroid function to manage symptoms effectively and reduce the risk of complications associated with hyperthyroidism.

MTHFR

The MTHFR (methylenetetrahydrofolate reductase) gene plays a critical role in folate metabolism, influencing the conversion of homocysteine to methionine and regulating DNA synthesis and repair. MTHFR gene mutations have been associated with elevated homocysteine levels, which are a risk factor for cardiovascular disease. MTHFR mutations may also impact neurotransmitter metabolism, potentially affecting mood regulation. Low folate levels due to impaired MTHFR function have been linked to an increased risk of depressive symptoms and poor response to antidepressant therapy in some individuals.

Testing for MTHFR mutations can provide valuable information for assessing cardiovascular risk and guiding personalized treatment strategies, including folate supplementation to optimize health outcomes related to both cardiovascular health and mood disorders.

MTHFR & COMT

Testing for both MTHFR and COMT genetic variants together can provide a more comprehensive understanding of how an individual metabolizes neurotransmitters and folate, influencing both mental health and overall well-being. Testing for both MTHFR and COMT together can provide a nuanced understanding of genetic influences on neurotransmitter metabolism and folate utilization, supporting personalized health interventions aimed at optimizing mental health and overall well-being.

Mold Sensitivity

Mold sensitivity, often associated with conditions like chronic inflammatory response syndrome (CIRS), can be influenced by genetic factors, including variations in the HLA (human leukocyte antigen) genes. Testing for these HLA gene variants can provide insights into an individual's genetic predisposition to mold sensitivity and related health conditions. This information can help guide environmental interventions, personalized treatment strategies, and lifestyle modifications aimed at reducing exposure and managing symptoms associated with mold-related illnesses.

Mood Profile

Offering a comprehensive mood profile through DNA testing, we analyze mutations in genes like MTHFR and COMT, crucial for neurotransmitter metabolism, alongside assessing levels of vitamin B12 and vitamin D. This personalized approach helps uncover genetic and nutritional factors influencing mood and mental health, guiding targeted interventions to support overall well-being.

Multiple Sclerosis

HLA-DRB1 testing is relevant in the context of multiple sclerosis (MS), an autoimmune disorder affecting the central nervous system. Certain variants of the HLA-DRB1 gene have been strongly associated with an increased risk of developing MS. Testing for HLA-DRB1 variants can help identify individuals who may be genetically predisposed to MS, aiding in early diagnosis, personalized treatment planning, and potentially influencing disease management strategies.

Narcolepsy

HLA-DRB1 and HLA-DQB1 are genetic markers associated with an increased susceptibility to narcolepsy, a chronic sleep disorder characterized by excessive daytime sleepiness and abnormal REM sleep patterns. Testing for HLA-DRB1 and HLA-DQB1 variants can aid in diagnosing narcolepsy and determining the likelihood of developing the disorder. Understanding these genetic predispositions can guide healthcare providers in identifying at-risk individuals early, facilitating appropriate management strategies and improving quality of life for patients with narcolepsy.

Nutritional Deficiencies

Deficiencies in essential vitamins and minerals can oftentimes go unnoticed and have been associated with risks of many adverse health effects. Recent and reputable scientific research has shown that individuals’ genes play a large role in these deficiencies. The Nutritional Deficiencies Panel was assembled by a team of researchers who have identified the scientific studies regarding the specific genes that increase susceptibility to nutritional disorders and deficiencies involving Vitamin A, Vitamin B12, Vitamin D, Folate, and Iron.

PGx Comprehensive

Cytochrome P450 activity is crucial for metabolizing medications like statins, opioids, and warfarin. We also analyze genetic markers affecting folate metabolism and thrombosis risk, empowering personalized treatment decisions to optimize medication effectiveness and safety.

Penicillin Hypersensitivity

HLA-B is a genetic marker associated with an increased risk of hypersensitivity reactions to penicillin and other beta-lactam antibiotics. Testing for specific variants can help identify individuals who may be predisposed to severe allergic reactions, allowing healthcare providers to choose alternative antibiotics or adjust treatment plans to avoid potential life-threatening reactions. This genetic testing supports safer prescribing practices and personalized medicine approaches in managing antibiotic allergies.

Rheumatoid Arthritis

HLA-DRB1 is a genetic marker strongly associated with an increased risk of developing rheumatoid arthritis (RA), an autoimmune disorder that primarily affects the joints. Testing for HLA-DRB1 variants can help identify individuals who may be at higher risk for developing RA, especially when combined with other clinical assessments and biomarkers. This information aids in early diagnosis, prognosis determination, and personalized treatment planning to manage symptoms and slow disease progression effectively.

Sjögren's Syndrome

HLA-B alleles have been associated with an increased risk of developing Sjögren's syndrome, an autoimmune condition characterized by dry eyes and dry mouth due to inflammation of the glands that produce tears and saliva. Testing for specific HLA-B variants can help identify individuals who may have a genetic predisposition to Sjögren's syndrome, aiding in early diagnosis and personalized management strategies to mitigate symptoms and complications associated with the disease.

Systemic Lupus Erythematosus

HLA-DRB1 is a genetic marker associated with systemic lupus erythematosus (SLE), a complex autoimmune disease that can affect multiple organs and tissues. Testing for HLA-DRB1 variants can help identify individuals who may be genetically predisposed to developing SLE. While HLA-DRB1 alone does not diagnose SLE, it can contribute to a comprehensive assessment when combined with clinical symptoms, other laboratory tests, and medical history. This genetic information aids in early diagnosis, personalized treatment planning, and monitoring of disease activity to improve outcomes for patients with SLE.

Weight Management

Testing for specific genetic variants in FTP, MC4R, FABP2, ADRP2, and SH2B1 can provide insights into an your individual genetic predisposition to weight-related issues, guiding personalized approaches to weight management strategies, including diet, exercise, and potentially pharmacological interventions.